MAPPFinder 1.0 Results for Local MAPPs File: C:\MAPPFinder Additional Files\FVBN Developmental Data from CardioGenomics.gex Statistics: 3858 Genes met the ([Embryo fold] > 1.2 and [Embryo permute p] < 0.05) or ([Embryo fold] < -1.2 and [Embryo permute p] < 0.05) criteria. 3453 Genes did not link to a MAPP. 405 genes were used to calculate the results shown below. The z score is based on an N of 951 and a R of 405 distinct genes. MAPPName Number Changed Number Measured Number on MAPP Percent Changed Percent Present z Score Mm_Ribosomal Proteins 33 45 69 73.3 65.2 4.101 Mm_Gene Trap Resource_2-04-02_Named Genes 102 182 358 56 50.8 3.437 Mm_Fatty Acid Degradation 11 13 15 84.6 86.7 3.05 Mm_TCA Cyle 10 12 24 83.3 50 2.842 Mm_Cholesterol Biosynthesis 7 8 11 87.5 72.7 2.562 Mm_Sarcomere 23 38 50 60.5 76 2.205 Mm_Fatty Acid Synthesis 5 6 11 83.3 54.5 2.015 Mm_Glycogen Metabolism 5 6 14 83.3 42.9 2.015 Mm_Cell cycle 10 15 18 66.7 83.3 1.876 Mm_Glycolysis and Gluconeogenesis 15 25 36 60 69.4 1.745 Mm_Translation Factors 14 24 32 58.3 75 1.546 Mm_C-21 Steroid Hormone Metabolism 1 1 2 100 50 1.161 Mm_Electron Transport Chain 11 20 58 55 34.5 1.114 Mm_Apoptosis 20 39 43 51.3 90.7 1.082 Mm_Androgen and Estrogen Metabolism 2 3 7 66.7 42.9 0.843 Mm_GPCRs, Class B Secretin-like 6 11 18 54.5 61.1 0.799 Mm_Pentose Phosphate Pathway 3 5 6 60 83.3 0.786 Mm_Gene Trap Resource_2-04-02_Named Genes 2 22 46 89 47.8 51.7 0.706 Mm_Proteasome Degradation 12 25 41 48 61 0.542 Mm_Complement Activation, Classical 5 10 12 50 83.3 0.472 Mm_Acetylcholine Synthesis 3 6 7 50 85.7 0.367 Mm_Catacholamine Biosynthesis 1 2 4 50 50 0.212 Mm_tRNA Synthetases 1 2 20 50 10 0.212 Mm_TGF Beta Signaling Pathway 13 30 48 43.3 62.5 0.082 Mm_Nucleotide GPCRs 2 5 7 40 71.4 -0.117 Mm_G13 Signaling Pathway 11 27 36 40.7 75 -0.192 Mm_Glucocorticoid & Mineralocorticoid Metabolism 3 9 13 33.3 69.2 -0.56 Mm_G Protein Signaling 17 45 69 37.8 65.2 -0.641 Mm_Nuclear Receptors 13 35 39 37.1 89.7 -0.643 Mm_Steroid Biosynthesis 4 12 14 33.3 85.7 -0.645 Mm_Alanine-Aspartate Metabolism 1 4 4 25 100 -0.711 Mm_Eicosanoid Synthesis 5 16 19 31.2 84.2 -0.912 Mm_S1P Signaling 3 11 22 27.3 50 -1.023 Mm_Inflammatory Response Pathway 12 36 41 33.3 87.8 -1.108 Mm_GPCRs, Class C Metabotropic glutamate, pheromone 1 6 12 16.7 50 -1.282 Mm_MAPK Cascade 5 20 26 25 76.9 -1.579 Mm_Wnt Signaling 15 49 62 30.6 79 -1.664 Mm_Calcium Channels 1 9 15 11.1 60 -1.904 Mm_Blood Clotting Cascade 3 16 21 18.8 76.2 -1.917 Mm_Monoamine GPCRs 5 23 33 21.7 69.7 -2.005 Mm_Gap Junction Proteins-Connexins 2 14 16 14.3 87.5 -2.131 Mm_Orphan GPCRs 3 18 22 16.7 81.8 -2.209 Mm_Small ligand GPCRs 1 12 17 8.3 70.6 -2.389 Mm_Matrix Metalloproteinases 1 15 25 6.7 60 -2.798 Mm_GPCRs, Other 2 19 240 10.5 7.9 -2.807 Mm_Peptide GPCRs 5 54 68 9.3 79.4 -4.853 Mm_GPCRs, Class A Rhodopsin-like 20 130 252 15.4 51.6 -5.979