MAPPFinder 1.0 Results for Local MAPPs File: C:\MAPPFinder Additional Files\FVBN Developmental Data from CardioGenomics.gex Statistics: 1728 Genes met the [embryo fold] < -1.2 AND[embryo permute p] < 0.05 criteria. 1560 Genes did not link to a MAPP. 168 genes were used to calculate the results shown below. The z score is based on an N of 951 and a R of 168 distinct genes. MAPPName Number Changed Number Measured Number on MAPP Percent Changed Percent Present z Score Mm_TCA Cyle 10 12 24 83.3 50 5.957 Mm_Fatty Acid Degradation 9 13 15 69.2 86.7 4.868 Mm_Glycolysis and Gluconeogenesis 12 25 36 48 69.4 3.966 Mm_Electron Transport Chain 9 20 58 45 34.5 3.198 Mm_Sarcomere 12 38 50 31.6 76 2.24 Mm_Fatty Acid Synthesis 3 6 11 50 54.5 2.076 Mm_Complement Activation, Classical 4 10 12 40 83.3 1.85 Mm_Nucleotide GPCRs 2 5 7 40 71.4 1.309 Mm_Nuclear Receptors 9 35 39 25.7 89.7 1.244 Mm_Glycogen Metabolism 2 6 14 33.3 42.9 1.006 Mm_Acetylcholine Synthesis 2 6 7 33.3 85.7 1.006 Mm_GPCRs, Class B Secretin-like 3 11 18 27.3 61.1 0.835 Mm_S1P Signaling 3 11 22 27.3 50 0.835 Mm_TGF Beta Signaling Pathway 7 30 48 23.3 62.5 0.811 Mm_Inflammatory Response Pathway 8 36 41 22.2 87.8 0.714 Mm_Androgen and Estrogen Metabolism 1 3 7 33.3 42.9 0.711 Mm_Cholesterol Biosynthesis 2 8 11 25 72.7 0.544 Mm_Apoptosis 8 39 43 20.5 90.7 0.464 Mm_G Protein Signaling 9 45 69 20 65.2 0.409 Mm_Alanine-Aspartate Metabolism 1 4 4 25 100 0.384 Mm_Proteasome Degradation 5 25 41 20 61 0.305 Mm_Pentose Phosphate Pathway 1 5 6 20 83.3 0.137 Mm_G13 Signaling Pathway 5 27 36 18.5 75 0.116 Mm_Eicosanoid Synthesis 3 16 19 18.8 84.2 0.114 Mm_Monoamine GPCRs 4 23 33 17.4 69.7 -0.034 Mm_GPCRs, Class C Metabotropic glutamate, pheromone 1 6 12 16.7 50 -0.064 Mm_Translation Factors 4 24 32 16.7 75 -0.128 Mm_Gap Junction Proteins-Connexins 2 14 16 14.3 87.5 -0.331 Mm_Cell cycle 2 15 18 13.3 83.3 -0.439 Mm_Calcium Channels 1 9 15 11.1 60 -0.515 Mm_Glucocorticoid & Mineralocorticoid Metabolism 1 9 13 11.1 69.2 -0.515 Mm_Small ligand GPCRs 1 12 17 8.3 70.6 -0.847 Mm_Steroid Biosynthesis 1 12 14 8.3 85.7 -0.847 Mm_MAPK Cascade 2 20 26 10 76.9 -0.897 Mm_Wnt Signaling 6 49 62 12.2 79 -0.99 Mm_Matrix Metalloproteinases 1 15 25 6.7 60 -1.115 Mm_Blood Clotting Cascade 1 16 21 6.2 76.2 -1.195 Mm_Orphan GPCRs 1 18 22 5.6 81.8 -1.345 Mm_GPCRs, Class A Rhodopsin-like 17 130 252 13.1 51.6 -1.352 Mm_GPCRs, Other 1 19 240 5.3 7.9 -1.415 Mm_Peptide GPCRs 4 54 68 7.4 79.4 -1.965 Mm_Gene Trap Resource_2-04-02_Named Genes 2 3 46 89 6.5 51.7 -1.972 Mm_Gene Trap Resource_2-04-02_Named Genes 20 182 358 11 50.8 -2.315 Mm_Ribosomal Proteins 1 45 69 2.2 65.2 -2.703