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Open Access Open Badges Protein family review

SUMO-specific proteases/isopeptidases: SENPs and beyond

Arnab Nayak and Stefan Müller*

Author Affiliations

Institute of Biochemistry II, Goethe University, Faculty of Medicine, Theodor-Stern-Kai 7, Frankfurt, 60590, Germany

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Genome Biology 2014, 15:422  doi:10.1186/s13059-014-0422-2

Published: 31 July 2014


We summarize the evolutionary relationship, structure and subcellular distribution of SUMO proteases (or SUMO isopeptidases). We also discuss their functions and allude to their involvement in human disease.

SUMO; SUMO isopeptidase; SUMO-specific protease; SENP; Desi-1; Desi-2; USPL1