Figure 5.

TE methylation in the proximity of genes with different expression levels. CG methylation levels of TEs located upstream or downstream of highly expressed genes (top 25%; red dots) and lowly expressed genes (bottom 25%; blue dots). Red (highly expressed genes) and blue (lowly expressed genes) lines represent the moving average of methylation levels in 100 bp windows. t-Test P-values of the differences in percentage TE methylation between highly and lowly expressed genes were 2.2 × 10-16 for TE-gene distances ≤0.5 kb and ≤10-5 for TE-gene distances between 0.5 and 1 kb.

Montanini et al. Genome Biology 2014 15:411   doi:10.1186/s13059-014-0411-5
Download authors' original image