Additional file 7: Figure S5.
Further examples of de-repressed ORR1A0 transcripts in the absence of KLF3. As in Figure 6, tracks represent RNA-Seq reads and splicing events for Klf3+/+ (WT) and Klf3−/− (KO) E14.5 TER119+ fetal liver cell samples. (A, B)ORR1A0 elements are transcribed and spliced to downstream exons of Znrf2 (A) and Brca2(B), which in turn are expressed at a significantly higher level in KO cells. (C) Spliced transcripts initiating nearby to an ORR1A0 LTR are antisense to an annotated gene (Dhx57). (D) De-repressed transcription of an ORR1A0/ORR1A0-int cassette does not alter the expression of the surrounding gene (Drosha).
Format: TIFF Size: 2MB Download file
Mak et al. Genome Biology 2014 15:R58 doi:10.1186/gb-2014-15-4-r58