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Target competition: transcription factors enter the limelight

Florian A Karreth12, Yvonne Tay1 and Pier Paolo Pandolfi1*

Author Affiliations

1 Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA

2 Meyer Cancer Center, Weill Cornell Medical College, New York, NY 10021, USA

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Genome Biology 2014, 15:114  doi:10.1186/gb4174

Published: 28 April 2014


Transcription factor binding sites compete for a limited pool of bioavailable transcription factor molecules to fine tune gene expression.