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Methods for comprehensive experimental identification of RNA-protein interactions

Colleen A McHugh, Pamela Russell and Mitchell Guttman*

Author Affiliations

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA

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Genome Biology 2014, 15:203  doi:10.1186/gb4152

Published: 27 January 2014


The importance of RNA-protein interactions in controlling mRNA regulation and non-coding RNA function is increasingly appreciated. A variety of methods exist to comprehensively define RNA-protein interactions. We describe these methods and the considerations required for designing and interpreting these experiments.