Figure 7.

The non-coding RNA (ncRNA) 7SK has a central role in controlling transcription in embryonic stem cells.7SK is required for the repression of genes that are silent or expressed at a low level. Widespread failed transcriptional termination was also seen after 7SK knockdown. 7SK is a major regulator of transcriptional directionality, by preventing the transcription of upstream divergent RNAs (udRNAs).

Castelo-Branco et al. Genome Biology 2013 14:R98   doi:10.1186/gb-2013-14-9-r98
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