Additional file 6.

Embryonic development in MommeD mutants. Tabulated data shows the number of observed mice and in brackets the percentage of total. (a) Intercrosses of Pbrm1MommeD27 mice produce no homozygous offspring at three weeks. (b)Brd1MommeD42 homozygous mice are embryonic lethal around 10.5 dpc. (c) Mice carrying mutations in Suv39h1MommeD33 are viable at three weeks. (d)Uhrf1MommeD40 homozygotes are embryonic lethal around 10.5 dpc. (e) Some homozygous Baz1bMommeD16 mice were obtained at three weeks but less than expected. (f) No (Smchd1MommeD36) or few (Smchd1MommeD23) homozygous individuals were recovered from intercrosses. The Smchd1MommeD23 homozygotes that survived were males. (g)Trim28MommeD31 homozygous mice are embryonic lethal prior to 10.5 dpc. (h) Mice homozygous for the Dnmt1MommeD32 mutation die around 10.5 dpc. (i) Intercrosses of Smarca5MommeD35 and Smarca5MommeD37 produced no homozygous offspring at three weeks. Timed matings show that survival of homozygous mutants at 12.5 to 14.5 dpc was rare in Smarca5MommeD35 mutants. In Smarca5MommeD37 mutants homozygous embryonic death occurred prior to 14.5 dpc.

Format: PDF Size: 64KB Download file

This file can be viewed with: Adobe Acrobat Reader

Daxinger et al. Genome Biology 2013 14:R96   doi:10.1186/gb-2013-14-9-r96