Identification of nucleic acid binding proteins (NABPs) in human cell lines. (a) Outline of the experiments and analyses performed. GO, Gene Ontology. (b) The affinity purification strongly enriched the identified proteins from the known NABPs (individual pulldowns summarized in the boxes) compared to human Swiss-Prot content (dashed line) and the three cell line core proteomes (red lines). (c) Comparison of the known NABPs in the union of the three core proteomes and all the affinity purification experiments (isoforms were collapsed for better comparability). (d) Proportion of annotated transcription factors (TFs) present in the core proteomes (red lines), the purifications (boxes), and Swiss-Prot (dashed lines) compared.
Dürnberger et al. Genome Biology 2013 14:R81 doi:10.1186/gb-2013-14-7-r81