Highly Accessed Open Badges Correspondence

The advantages of SMRT sequencing

Richard J Roberts1*, Mauricio O Carneiro2 and Michael C Schatz3

Author Affiliations

1 New England Biolabs, 240 County Road, Ipswich, MA 01938, USA

2 Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA

3 Simons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11743, USA

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Genome Biology 2013, 14:405  doi:10.1186/gb-2013-14-7-405

Published: 3 July 2013


Of the current next-generation sequencing technologies, SMRT sequencing is sometimes overlooked. However, attributes such as long reads, modified base detection and high accuracy make SMRT a useful technology and an ideal approach to the complete sequencing of small genomes.