Mutation occurrence and correlation with gene length of known, candidate and rest of mutated genes. Occurrence of mutated genes in 20 cancer types (A) and 3,052 samples (B). None of the 10,681 genes is mutated in all 20 cancer types or samples; TP53 is the only gene to be mutated in 19 cancer types, while >40% of genes are mutated only in one cancer type. (C) Dependence of the recurrence of mutations on the gene length. Plotted is the length distribution of the coding portion for all genes that were found mutated in one to 20 cancer types. The interpolation line and R2 were calculated using the LM function in R.
D'Antonio and Ciccarelli Genome Biology 2013 14:R52 doi:10.1186/gb-2013-14-5-r52