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Deep C diving: mapping the low-abundance modifications of the DNA demethylation pathway

John P Thomson, Jennifer M Hunter and Richard R Meehan*

Author Affiliations

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK

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Genome Biology 2013, 14:118  doi:10.1186/gb-2013-14-5-118

Published: 29 May 2013


Two new studies imply that the reprogramming of 5-methylcytosine via TET- and TDG-family enzymes is both widespread throughout the genome and functionally significant.