Correlation of DNA content variability with genome characteristics. The middle panel shows aCGH results comparing BN blood versus BN liver DNA and is aligned with replication timing (early replication is represented by high values, data obtained from Ryba et al. ), SINE distribution, GC content (100 kb windows), and gene density. Pearson correlation scores (r) are given per comparison. For each, P values are < 0.001. For this visualization, genomic positions of rat aCGH data were translated to positions on the first 50 Mb of human chromosome 2 (HSA2) to be able to compare rat data with human data on replication timing.
van Heesch et al. Genome Biology 2013 14:R33 doi:10.1186/gb-2013-14-4-r33