Detailed visualization of chromothripsis in a breast-cancer cell line. On chromosome 17 of the breast-cancer cell line HCC2218, total copy number varies on the q-arm whereas the minor copy number stays at 1. This is consistent with one of the homologs having undergone chromothripsis. Top panel: Scatter plot of allelic imbalance ratio and normalized coverage for segments on chromosome 17, colored in blue-red gradient. Grey segments are those located on other chromosomes. Bottom panel: Total copy number in blue-red gradient depending on chromosomal location. Grey indicates minor copy number.
Mayrhofer et al. Genome Biology 2013 14:R24 doi:10.1186/gb-2013-14-3-r24