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Characterizing 5-methylcytosine in the mammalian epitranscriptome

Shobbir Hussain*, Jelena Aleksic, Sandra Blanco, Sabine Dietmann and Michaela Frye*

Author Affiliations

Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK

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Genome Biology 2013, 14:215  doi:10.1186/gb4143

Published: 29 November 2013


The post-transcriptional modification 5-methylcytosine (m5C) occurs in a wide range of coding and non-coding RNAs. We describe transcriptome-wide approaches to capture the global m5C RNA methylome. We also discuss the potential functions of m5C in RNA and compare them to 6-methyladenosine modifications.