Fixated on fixation: using ChIP to interrogate the dynamics of chromatin interactions
1 Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 76100, Israel
2 Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
Genome Biology 2013, 14:138 doi:10.1186/gb4139Published: 21 November 2013
A new study exploits the time-dependence of formaldehyde cross-linking in the commonly used chromatin immunoprecipitation (ChIP) assay to infer the on and off rates for site-specific chromatin interactions.