Studying the conservation of DNAm age in tissues from great apes. Analysis of two independent data sets involving tissues from great apes. (A,B) Results for data set 72 . A high age correlation (cor = 0.84, error = 10 years) can be observed when studying both chimpanzee heart (colored grey) and human heart tissue (colored turquoise) samples. To facilitate a comparison, I also added the heart tissue data from data set 25 (blue circles). (B) DNAm age is closely related to chronological age (cor = 0.75, error = 3.7) across kidney and liver samples from humans (turquoise) and chimpanzees (grey). (C-F) Results for ape blood samples from data set 73. (C) Highly accurate results (cor = 0.9, error = 1.4) can be observed for blood samples from common chimpanzees (Pan troglodytes; labeled C, colored blue) and bonobos (Pan paniscus; labeled B, colored turquoise). (D) Results for common chimpanzees only. (E) Results for bonobos only. (F) Results for gorillas.
Horvath Genome Biology 2013 14:R115 doi:10.1186/gb-2013-14-10-r115