Additional file 6: Figure S3.
MassArray-based confirmation and external validation of the differentially methylated loci. (A,D) Average HpaII/MspI methylation ratio of DMRs on the HELP array in control (blue) and CKD kidneys (red). The original data can be found in Additional file 3. (B,E) MassArray Epityper-based absolute methylation level of the locus for control (blue) and CKD kidneys (red). Note that one HELP probe represents multiple CpG sites. (C,F) Methylation difference between DKD and control for this region in the external validation dataset. This dataset was generated using the Illumina Infinium 450K arrays from 66 control and 21 DKD microdissected kidney samples. The original data can be found in Additional file 7). (A-C) Changes in the Dermatopontin gene (DPT); (D-F) changes in the Down syndrome cell adhesion molecule (DSCAM) locus.
Format: PPTX Size: 73KB Download file
Ko et al. Genome Biology 2013 14:R108 doi:10.1186/gb-2013-14-10-r108