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Genome-wide mapping of FOXM1 binding reveals co-binding with estrogen receptor alpha in breast cancer cells

Deborah A Sanders1, Caryn S Ross-Innes1, Dario Beraldi1, Jason S Carroll12* and Shankar Balasubramanian134*

Author Affiliations

1 Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, UK

2 Department of Oncology, University of Cambridge, Cambridge, CB2 0RE, UK

3 Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK

4 School of Clinical Medicine, The University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0SP, UK

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Genome Biology 2013, 14:R6  doi:10.1186/gb-2013-14-1-r6

Published: 24 January 2013

Additional files

Additional file 1:

Supplementary materials and methods, tables and figures as mentioned in the text.

Format: PDF Size: 3.3MB Download file

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Additional file 2:

FOXM1 binding peaks in MCF7 cells. Excel spreadsheet containing the location of FOXM1 binding peaks identified using MACS in replicate samples of MCF7 cells treated with DMSO or thiostrepton. Differential bound peaks (FDR < 0.05) were identified using edgeR.

Format: XLSX Size: 2.2MB Download file

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Additional file 3:

Differentially expressed gene list from microarray analysis. Excel spreadsheet with details of differentially expressed gene (FDR < 0.01) from microarray analysis for DMSO versus thiostrepton-treated MCF7 cells.

Format: XLSX Size: 1.3MB Download file

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Additional file 4:

FOXM1 binding peaks from DBA versus expression changes from microarray. Excel spreadsheet containing LogFC values for differential expression of genes with TSSs located within ± 50 kb of differentially bound FOXM1 identified from DBA in MCF7 cells treated with DMSO or thiostrepton.

Format: XLSX Size: 5.8MB Download file

Open Data