Additional file 7.

Escherichia/Shigella abundance is significantly decreased in mesalamine-treated subjects. The association of these genera (indistinguishable by 16S rRNA gene sequencing) with disease status and clinical metadata (including mesalamine treatment) was determined to be significant using a sparse general linear model (see Materials and methods). Clade abundances were transformed with the arcsine square root transformation for proportional data and are plotted along the y-axis as two notched box plots (samples without and with mesalamine use). Size of effect, standard deviation, P-value (p) and q-value (q) are shown in parentheses.

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Morgan et al. Genome Biology 2012 13:R79   doi:10.1186/gb-2012-13-9-r79