Association of TCF7L2 and HNF4α in HepG2 cells. (a) HNF4α and FOXA2 ChIP-seq data were downloaded from the UCSC genome browser, and peaks were called and overlapped with the HepG2 cell type-specific TCF7L2 peaks. (b) Peaks bound only by HNF4α, only by TCF7L2, or by both factors were analyzed for the presence of HNF4α and TCF7L2 motifs. (c) For the set of 7,576 peaks bound by all three factors, the location of the HNF4α and FOXA2 peaks were plotted relative to the center of the TCF7L2 peak. (d) A comparison of TCF7L2, HNF4α, and FOXA2 binding patterns near the GREB1 locus is shown. The hg19 genomic coordinates are chr2:11,636,208-11,708,654. The number of tags reflecting the ChIP enrichments is plotted on the y-axis.
Frietze et al. Genome Biology 2012 13:R52 doi:10.1186/gb-2012-13-9-r52