Additional file 1.

Supplementary figures S1 to S7 and Supplementary note. Figure S1: individual variation of bound and unbound Twi, Bin and Tin motifs. Figure S2: relationship between cross-species variation and information content at Twi, Bin and Tin motifs. Figure S3: general distributions of TFBS load in Drosophila and human. Figure S4: additional information for the analysis of TFBS load relative to PWM match score. Figure S5: distributions of TFBS load along Drosophila chromosome arms. Figure S6: additional information on the per-individual analysis of CTCF binding. Figure S7: naturally occurring mutations at mesodermal TFBSs do not affect in vitro CRM activity. Supplementary note: selection of TF binding motifs for the analysis.

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Spivakov et al. Genome Biology 2012 13:R49   doi:10.1186/gb-2012-13-9-r49