Framework for assessing confidence in a HTP PPI screen. Coev2Net, trained on a high-quality PPI network, is able to assign structure-based confidence scores for HTP PPI networks. Each node represents a protein and each edge the putative interaction between the two proteins. The thickness of an edge describes structure-based confidences of putative PPIs.
Hosur et al. Genome Biology 2012 13:R76 doi:10.1186/gb-2012-13-8-r76