Promoters bound by Brd- and HP1-bound nucleosomes. (a) Heatmap of promoters with nucleosomes bound by the Brd and HP1 proteins. Heatmaps are arranged as clusters of promoters bound by the various ChIPs (lanes 1 to 5: bound, red; unbound, blue) and the expression of these genes from RNA-Seq is represented in lane 6 (high and medium, red; silent, blue). (b) Ranked order table of genes (top 35) whose promoters are bound by the Brd and HP1 proteins. Genes are ordered based on Brd/HP1 binding score within the promoter region of all annotated genes (top of the list, most bound). Genes belonging to the HOX clusters or ZNF clusters are color coded accordingly. (c) HP1α and HP1β binding clusters on chromosome 19. The ZNF clusters are labeled 1 to 6.
LeRoy et al. Genome Biology 2012 13:R68 doi:10.1186/gb-2012-13-8-r68