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## Figure 5.
Experimental validation of G. TFs_{0 }Figure 5A: Viability of ΔTF strains in contrast to wildtype and negative controls, shown as
a hierarchically clustered heat-map. Strains are shown vertically and time-points
in days horizontally, coloured cells denote log fold change of viability (red - increased
viability, blue - decreased viability). Asterisks denote statistical significance
of fold change (linear regression, LR test, FDR p ≤ 0.05). Inviable strains with viability less than CFU = 0.005 are labeled with the
symbol #. Time-point on day one corresponds to exponentially growing cells, measured
seven hours after inoculation. Figure 5B: High-resolution viability curves of the first 72 hours of the time-course covering
exponential growth, diauxic shift and post-diauxic phase. A subset of ΔTF strains
(coloured solid lines), as well as wildtype strains (black solid lines) and controls
(dashed and dotted lines) are shown. Figure 5C: G_{0 }viability curve of super-wildtype strain Δbas1. Figure 5D: Viability curve of G_{0}-essential strain Δ tup1. Figure 5E: Viability curve of positive control strain Δmip1. Figure 5F: Viability curve of negative control strain Δtup1. TF, transcription factor knockout strain; FDR, false discovery rate.
Reimand |