Additional file 3.

Module preservation analysis. The figures report the results of the module preservation analysis in the validation data sets. Each figure (page) corresponds to one validation data set. The left and right panels of each figure show the results for the Zdensity and medianRank statistics, respectively. The higher the value of the Zdensity statistic (and the lower the value of the median rank statistic), the stronger the evidence that the consensus module (based on the ten reference data sets) is preserved in the validation data set. The Zdensity statistic is based on a permutation test that allows one to establish significance thresholds (that are indicated by the horizontal lines at values 2 and 5 in the left panel). Values of Zdensity larger than 5 indicate moderate preservation while values below 2 indicate no evidence of preservation.

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Horvath et al. Genome Biology 2012 13:R97   doi:10.1186/gb-2012-13-10-r97