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This article is part of a special issue on exome sequencing.

Highly Accessed Open Badges Editorial

Next-generation human genetics

Jay Shendure

Author Affiliations

University of Washington, Department of Genome Sciences, Foege Building S- 250, Box 355065, 3720 15th Ave NE, Seattle, WA 98195-5065, USA

Genome Biology 2011, 12:408  doi:10.1186/gb-2011-12-9-408

Published: 14 September 2011


The field of human genetics is being reshaped by exome and genome sequencing. Several lessons are evident from observing the rapid development of this area over the past 2 years, and these may be instructive with respect to what we should expect from 'next-generation human genetics' in the next few years.