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An integrated strategy for identification of both sharp and broad peaks from next-generation sequencing data

Weiqun Peng1 and Keji Zhao2

Author Affiliations

1 Department of Physics, The George Washington University, 725 21st Street NW, Washington DC, 20052, USA

2 Laboratory of Molecular Immunology, National Heart, Lung and Blood Institute, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA

Genome Biology 2011, 12:120  doi:10.1186/gb-2011-12-7-120

Published: 25 July 2011


A novel integrative approach has been developed by Lieb and colleagues for analyzing genome-wide datasets of different chromatin-binding factors and epigenetic states that exhibit both sharp and diffuse signals on the genome.

See research article:

ChIP-Seq; algorithms; SICER; ZINBA; Chromatin States; Epigenetics; epigenome