Figure 2.

Phenotypic screening of genetically modified mice. Mutant mice available to the community are systematically screened for a range of phenotypes by the Sanger Mouse Genetics Project and the data published online [10]. Some examples of observed phenotypes are shown. (a) An outwardly protruding xiphoid process in Fam73btm1a(KOMP)Wtsi homozygous mice (top), compared with wild-type controls (bottom). (b) The formation of uroliths (bladder stones) in Clnd16tm1a(KOMP)Wtsi homozygous mice (top), not present in controls (bottom). (c) Underdeveloped molars in Sparctm1a(EUCOMM)Wtsi homozygous mice (top), compared with control mice (bottom). (d) Abnormal skeletal muscle in Zfp106tm1a(KOMP)Wtsi homozygous mice (top), compared with controls (bottom). (e) A shortened, upturned snout in Smc3tm1a(EUCOMM)Wtsi heterozygous mice. (f) Metacarpophalangeal joint fusion in Dnase1l2tm1(KOMP)Wtsi homozygous mice. (g) Spots of retinal hyperpigmentation in Slc9a8tm1a(KOMP)Wtsi homozygous mice. (h) LacZ reporter gene expression in the adult mammary gland of Myh9tm1a(EUCOMM)Wtsi heterozygous mice.

van der Weyden et al. Genome Biology 2011 12:224   doi:10.1186/gb-2011-12-6-224
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