Presence of Alus containing HSF sites in 5-kb proximal regions of antisense signals. HSF sites are especially enriched in the upstream (approximately 2-kb) region of the antisense transcript signal. Antisense transcripts may be transcribed through HSF binding to Alu repeats, leading to down-regulation of sense transcripts in response to heat shock.
Pandey et al. Genome Biology 2011 12:R117 doi:10.1186/gb-2011-12-11-r117