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Whole genome sequencing of penicillin-resistant Streptococcus pneumoniae reveals mutations in penicillin-binding proteins and in a putative iron permease

Fereshteh Fani, Philippe Leprohon, Danielle Légaré and Marc Ouellette*

Author Affiliations

Centre de recherche en Infectiologie du Centre de recherche du CHUL and Département de Microbiologie, Infectiologie et Immunologie, Faculté de Médecine, Université Laval, 2705 Boul. Laurier, Québec, Canada

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Genome Biology 2011, 12:R115  doi:10.1186/gb-2011-12-11-r115

Published: 22 November 2011

First paragraph (this article has no abstract)

Penicillin resistance in Streptococcus pneumoniae is mediated by a mosaic of genes encoding altered penicillin-binding proteins (PBPs). Nonetheless, S. pneumoniae has also developed non-PBP mechanisms implicated in penicillin resistance. In this study, whole genome sequencing of resistant organisms was used to discover mutations implicated in resistance to penicillin.