Performance of TAPS and three other methods in identifying aberrations influenced by normal cell content. The performace of TAPS is compared to three other methods, PICNIC, PSCN and GAP. (a) Sensitivity as the percentage of correctly identified out of 35 large aberrations. (b) Sensitivity in the subset of (a) with loss of heterozygosity (n = 14). (c) Specificity as the percentage of unaltered genome that was correctly reported as unaltered. All methods showed high specificity, partially due to some of them reporting everything as unchanged at low tumor cell content.
Rasmussen et al. Genome Biology 2011 12:R108 doi:10.1186/gb-2011-12-10-r108