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This article is part of the supplement: Beyond the Genome: The true gene count, human evolution and disease genomics

Open Badges Invited speaker presentation

Genomic variation and adaptation in Africa: implications for human evolutionary history and disease

Sarah A Tishkoff12*, Michael Campbell1, Jibril Hirbo1, Joe Jarvis1, Wen-Ya Ko1, Charla Lambert1, Alessia Ranciaro1, Laura Scheinfeldt1 and Sameer Soi1

  • * Corresponding author: Sarah A Tishkoff

Author Affiliations

1 Department of Genetics, University of Pennsylvania, Philadelphia, PA 19104-6145, USA

2 Department of Biology, University of Pennsylvania, Philadelphia, PA 19104-6145, USA

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Genome Biology 2010, 11(Suppl 1):I20  doi:10.1186/gb-2010-11-s1-i20

The electronic version of this article is the complete one and can be found online at:

Published:11 October 2010

© 2010 Tishkoff et al; licensee BioMed Central Ltd.

Invited speaker presentation

Africa contains the greatest levels of human genetic variation and is the source of the worldwide range expansion of all modern humans. However, relatively little is known about genomic variation in ethnically diverse African populations. Knowledge of genetic structure within Africa has important implications for the design and implementation of disease association studies in Africans and in African Americans, and for reconstructing modern human origins. In addition, studies of genetic adaptation in Africa have important implications for identifying genes that play an important role in human evolution and disease. The African populations included in this study practice diverse subsistence patterns and have diverse diets (e.g. the study includes hunter-gatherers, pastoralists, agriculturalists and agro- pastoralists). The populations studied live in diverse environments with differing pathogen exposure (tropical forest, savannah, coastal, desert, low altitude and high altitude) and, therefore, are likely to have experienced local adaptation. In this talk I will discuss results of analyses of genome-scale microsatellite and SNP genotyping data in a large set of geographically, linguistically and ethnically diverse African populations, as well as locus- specific analyses of genes that play a role in adaptation to diet and infectious disease. Implications for future whole genome sequencing analyses will be discussed.