Conservation of lncRNA expression in developing avian and mammalian brains. (a-c) Digoxigenin-labeled riboprobes complementary to lncRNAs AK043754 (a), AK082072 (b), and AK082467 (c) were hybridized to chicken (E4, 6, 8,12), opossum (P12, 20), and mouse (E13, 15, 17, 18 and P0) brain sections. (a) AK043754: strong hybridization seen in the germinal zone of the telencephalic cortex at early developmental time points (red arrowheads) and then concentrated within the piriform (olfactory) cortex at later stages (black arrowheads). (b) AK082072: hybridization signals seen in the stria terminalis (red arrowheads) and the telencephalic ventricular zone (green arrowheads). Signal was undetectable at later developmental stages. (c) AK082467: hybridization signals seen in the ventricular zone of the hippocampal formation (green arrowheads), the preoptic area of the hypothalamus (red arrowheads), and the epithalamus (black arrowheads). Signal was undetectable at later developmental stages. Scale bars = 200 μm.
Chodroff et al. Genome Biology 2010 11:R72 doi:10.1186/gb-2010-11-7-r72