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Escape from X inactivation in mice and humans

Joel B Berletch1, Fan Yang1 and Christine M Disteche12*

Author Affiliations

1 Department of Pathology, University of Washington, Seattle, Washington 98195, USA

2 Department of Medicine, University of Washington, Seattle, Washington 98195, USA

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Genome Biology 2010, 11:213  doi:10.1186/gb-2010-11-6-213

Published: 24 June 2010


A subset of X-linked genes escapes silencing by X inactivation and is expressed from both X chromosomes in mammalian females. Species-specific differences in the identity of these genes have recently been discovered, suggesting a role in the evolution of sex differences. Chromatin analyses have aimed to discover how genes remain expressed within a repressive environment.