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Constructing a fish metabolic network model

Shuzhao Li12*, Alexander Pozhitkov13, Rachel A Ryan1, Charles S Manning1, Nancy Brown-Peterson1 and Marius Brouwer1

Author Affiliations

1 Gulf Coast Research Laboratory, Department of Coastal Sciences, University of Southern Mississippi, 703 East Beach Drive, Ocean Springs, MS 39564, USA

2 Current address: Emory Vaccine Center, 954 Gatewood Rd, Atlanta, GA 30329, USA

3 Current address: Max Planck Institute, August-Thienemann-Str. 2, Ploen 24306, Germany

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Genome Biology 2010, 11:R115  doi:10.1186/gb-2010-11-11-r115

Published: 29 November 2010


We report the construction of a genome-wide fish metabolic network model, MetaFishNet, and its application to analyzing high throughput gene expression data. This model is a stepping stone to broader applications of fish systems biology, for example by guiding study design through comparison with human metabolism and the integration of multiple data types. MetaFishNet resources, including a pathway enrichment analysis tool, are accessible at webcite.