Systematic detection of putative tumor suppressor genes through the combined use of exome and transcriptome sequencing
- Equal contributors
1 Ludwig Collaborative Group, Department of Neurosurgery, Johns Hopkins University, 1550 Orleans Street, Baltimore, MD 21231, USA
2 J. Craig Venter Institute, 9704 Medical Center Drive, Rockville, MD 20850, USA
3 Ludwig Institute for Cancer Research, São Paulo Branch at Hospital Alemão Oswaldo Cruz, Rua João Julião 245, 01323-903 São Paulo, Brazil
4 Ludwig Institute for Cancer Research, San Diego Branch, 9500 Gilman Drive, La Jolla, CA 92093-0660, USA
5 Scripps Translational Science Institute, 3344 North Torrey Pines Court, La Jolla, CA 92037, USA
6 Laboratório Nacional de Computação Científica, Laboratório de Bioinformática, Av. Getúlio Vargas 333, Petrópolis, RJ 25651-075, Brazil
Genome Biology 2010, 11:R114 doi:10.1186/gb-2010-11-11-r114Published: 25 November 2010
Additional file 1:
Supplemental tables. Table S1: exome genotyping in HCC1954. Table S2: exome genotyping in HCC1954BL. Table S3: LOH genes in HCC1954. Table S4: LOH genes in HCC1954BL. Table S5: ASE genes in HCC1954. Table S6: ASE genes in HCC1954BL. Table S7: primers used in ASE events validation. Table S8: summary of putative tumor suppressor genes identified by LOH and ASE events.
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Additional file 2:
Supplemental figures. LOH events detected across each chromosome.
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