FLN-based disease gene prioritization shows improvement over PPI network. Gene-centric assessment (as described in the legend of Figure 4b) is used to compare the disease-gene prioritization performances between the integrated FLN and a representative PPI network. The PPI network is composed of curated PPI databases [45-51], along with high-throughput PPI data from yeast two-hybrid and mass spectrometry [52-54], and interactions mapped from PPI of other model organisms. The artificial chromosomal region composed of a collection of 100 nearest genes flanking each tested disease gene physically on the chromosome is used as the background gene set. Here, we exclude text mining data from the FLN.
Linghu et al. Genome Biology 2009 10:R91 doi:10.1186/gb-2009-10-9-r91