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DNA breaks as triggers for antigenic variation in African trypanosomes

Sam Alsford, David Horn* and Lucy Glover

Author Affiliations

London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK

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Genome Biology 2009, 10:223  doi:10.1186/gb-2009-10-6-223

Published: 8 June 2009


The DNA repair machinery has been co-opted for antigenic variation in African trypanosomes. New work directly demonstrates that a double-strand break initiates a switch in the expressed variant surface coat.