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Ancestry-related assortative mating in Latino populations

Neil Risch123*, Shweta Choudhry4, Marc Via14, Analabha Basu1, Ronnie Sebro1, Celeste Eng4, Kenneth Beckman5, Shannon Thyne1, Rocio Chapela6, Jose R Rodriguez-Santana7, William Rodriguez-Cintron8, Pedro C Avila9, Elad Ziv14 and Esteban Gonzalez Burchard14

Author Affiliations

1 Institute for Human Genetics, University of California, San Francisco, 513 Parnassus Ave, San Francisco, CA 94143, USA

2 Division of Research, Kaiser Permanente, 2000 Broadway, Oakland, CA 94612, USA

3 Department of Epidemiology and Biostatistics, University of California, San Francisco, 185 Berry Street, San Francisco, CA 94107, USA

4 Department of Medicine, University of California, San Francisco, 1550 4th St, San Francisco, CA 94143, USA

5 Biomedical Genomics Center, University of Minnesota, 426 Church St, Minneapolis, MN 55455, USA

6 Instituto Nacional de Enfermedades Respiratorias, Calzada de Tlalpan 4502, Col. Seccion XVI, CP 14080, Tlalpan, Distrito Federal, Mexico

7 Centro de Neumologia Pediatrica, CSP, 735 Ave Ponce de Leon, San Juan, 00917 Puerto Rico

8 Veterans Caribbean Health Care System, 10 Casia St, San Juan, 00921 Puerto Rico

9 Division of Allergy-Immunology, Feinberg School of Medicine, Northwestern University, 676 N St Clair St, Chicago, IL 60611, USA

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Genome Biology 2009, 10:R132  doi:10.1186/gb-2009-10-11-r132

Published: 20 November 2009

Additional files

Additional data file 1:

Table S1: within spouse correlations in ancestry. Table S2: t-tests of ancestry differences between spouses and between recruitment sites. Table S3: mean (standard deviation) ancestry by socioeconomic status. Table S4: regression of wife's IA on husband's IA and socioeconomic status. Table S5: allele frequency difference chi-square tests between sites and spouses. Table S6: regression of chi-square for Mexico versus US allele frequency difference on δ2N*/p*q*. Table S7: regression of LD chi-square tests on (δ1δ2)2/pqrs. Table S8: outlier marker pairs from regressions on D. Table S9: list of ancestry informative markers used in the current study.

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Additional data file 2:

Figure S1: Q-Q plot of residuals from regressions of allelic correlations F1 and F2 for (a) Mexicans and (b) Puerto Ricans. Figure S2: Q-Q plot of residuals from regression analysis of the linkage disequilibrium parameter D.

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