Comparison of molecular distances from baseline samples with unsupervised condition clustering. The list of 2,785 transcripts identified in the unsupervised analysis (Figure 2) was used to compute the 'molecular distance' between samples from patients with sepsis and uninfected control samples. (a, b) Region R1 for the training set (a) and R6 for the first test set (b) were used as the baseline uninfected controls for all comparisons. Molecular distances for individual subjects are indicated on a histogram that is aligned against the hierarchical condition tree generated through unsupervised clustering (Figure 2). Study group is marked as follows: patients with melioidosis are indicated by pink rectangles; patients with sepsis due to other organisms by green rectangles; uninfected controls who recovered from melioidosis by black rectangles; T2D patients by purple rectangles; and healthy donors by blue rectangles. Patients who died from sepsis are indicated by diagonal shading within the bars. Patients with severe sepsis are indicated by asterisks.
Pankla et al. Genome Biology 2009 10:R127 doi:10.1186/gb-2009-10-11-r127