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Transcriptional (dys)regulation and aging in Caenorhabditis elegans

Zachary Pincus and Frank J Slack*

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Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA

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Genome Biology 2008, 9:233  doi:10.1186/gb-2008-9-9-233

Published: 16 September 2008


A circuit of transcription factors has been discovered in Caenorhabditis elegans that could provide a link between laboratory-defined intracellular 'longevity pathways', gene dysregulation and the process of normal aging.