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The AAA+ superfamily of functionally diverse proteins

Jamie Snider, Guillaume Thibault and Walid A Houry*

Author Affiliations

Department of Biochemistry, University of Toronto, Medical Sciences Building, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada

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Genome Biology 2008, 9:216  doi:10.1186/gb-2008-9-4-216

Published: 30 April 2008


The AAA+ superfamily is a large and functionally diverse superfamily of NTPases that are characterized by a conserved nucleotide-binding and catalytic module, the AAA+ module. Members are involved in an astonishing range of different cellular processes, attaining this functional diversity through additions of structural motifs and modifications to the core AAA+ module.