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Deciphering histone 2A deubiquitination

Michael J Clague*, Judy M Coulson and Sylvie Urbé*

Author Affiliations

Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Crown St, Liverpool L69 3BX, UK

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Genome Biology 2008, 9:202  doi:10.1186/gb-2008-9-1-202

Published: 23 January 2008


Three recent papers have identified distinct enzymes that can remove ubiquitin from mammalian histone 2A (H2A). Functions in transcriptional activation, DNA repair and control of the cell cycle have been proposed for these enzymes.