This article is part of the supplement: Transposons in vertebrate functional genomics
Transposable elements in fish functional genomics: technical challenges and perspectives
Temasek Life Sciences Laboratory, Research Link, The National University of Singapore, 117604, Singapore
Genome Biology 2007, 8(Suppl 1):S6 doi:10.1186/gb-2007-8-s1-s6Published: 31 October 2007
The recent introduction of several transposable elements in zebrafish opens new frontiers for genetic manipulation in this important vertebrate model. This review discusses transposable elements as mutagenesis tools for fish functional genomics. We review various mutagenesis strategies that were previously applied in other genetic models, such as Drosophila, Arabidopsis, and mouse, that may be beneficial if applied in fish. We also discuss the forthcoming challenges of high-throughput functional genomics in fish.