Pam clustering over IR module in external ER- cohorts. Heatmap of gene expression of seven-gene IR-module in ER- samples of the (a) UPP and (b) JRH-2 cohorts. Shown are the clusters over-expressing (purple) and under-expressing (yellow) the IR module, as predicted by the pam algorithm. Good outcome samples are shown in gray, and poor outcome samples in black. Green indicates relative under-expression, and red indicates relative over-expression. (c) Kaplan-Meier survival curves over combined external cohorts (for UPP end-point was disease-specific survival, and for JRH-2 it was recurrence-free survival), with the number of events and samples in each of the two predicted groups. ER, estrogen receptor; pam, partitioning around medoids.
Teschendorff et al. Genome Biology 2007 8:R157 doi:10.1186/gb-2007-8-8-r157