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Pyrosequencing positions nucleosomes precisely

Tom Owen-Hughes* and Maik Engeholm

Genome Biology 2007, 8:217  doi:10.1186/gb-2007-8-6-217

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454 pyrosequencing C. elegans chromatin

Tom Owen-Hughes   (2007-07-25 15:02)  University of Dundee email

The article below describes the use of pyrosequencing to analyse chromatin structure in C.elegans.

Johnson SM, Tan FJ, McCullough HL, Riordan DP, Fire AZ.

Flexibility and constraint in the nucleosome core landscape of Caenorhabditis elegans chromatin.

Genome Res. 2006 Dec;16(12):1505-16. Epub 2006 Oct 12.

Unfortunately I had not read this at the time I prepared this minireview. However, I do believe it deserves credit as perhaps the first application of pyrosequencing to analyse chromatin structure.

Competing interests

None declared


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