Tilescope: online analysis pipeline for high-density tiling microarray data
1 Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
2 Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA
3 Department of Computer Science, Yale University, New Haven, CT 06520, USA
4 Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA
Genome Biology 2007, 8:R81 doi:10.1186/gb-2007-8-5-r81Published: 14 May 2007
We developed Tilescope, a fully integrated data processing pipeline for analyzing high-density tiling-array data http://tilescope.gersteinlab.org webcite. In a completely automated fashion, Tilescope will normalize signals between channels and across arrays, combine replicate experiments, score each array element, and identify genomic features. The program is designed with a modular, three-tiered architecture, facilitating parallelism, and a graphic user-friendly interface, presenting results in an organized web page, downloadable for further analysis.