Reactome: a knowledge base of biologic pathways and processes
1 European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK
2 Cold Spring Harbor Laboratory, Bungtown Road, Cold Spring Harbor, NY 11724, USA
3 NYU School of Medicine, First Avenue, New York, NY 10016, USA
4 College of Pharmacy and Allied Health Professions, St. John's University, Utopia Parkway, Queens, NY 11439, USA
5 Lawrence Berkeley National Laboratory, Cyclotron Road 64R0121, Berkeley, CA 94720, USA
Genome Biology 2007, 8:R39 doi:10.1186/gb-2007-8-3-r39Published: 16 March 2007
Reactome http://www.reactome.org webcite, an online curated resource for human pathway data, provides infrastructure for computation across the biologic reaction network. We use Reactome to infer equivalent reactions in multiple nonhuman species, and present data on the reliability of these inferred reactions for the distantly related eukaryote Saccharomyces cerevisiae. Finally, we describe the use of Reactome both as a learning resource and as a computational tool to aid in the interpretation of microarrays and similar large-scale datasets.